Background Chimeric antigen receptor T cell (CAR-T)-based immunotherapies Plasma Accessory have reshaped the therapeutic landscape of cancer treatment, in particular for patients afflicted with leukemia.However, defects in CAR behaviors and clinical complications have hindered their widespread application across diverse cancer types.Chief among the

In unilateral cleft lip, elevation of the cleft side of the philtrum follows the elevation of the whole philtrum, beginning from the point where the philtral ridge of the normal side meets the vermilion.To inferiorly rotate this segment of the lip, the incision line must pass through the entire width of the philtrum.If the incision is limited only

Abstract Among an assortment of genetic variations, Missense are major ones which a small subset of them may led to the upset of the protein function and ultimately end in human diseases.Various machine learning methods were declared to differentiate deleterious and benign missense variants by means of a large number of features, including structur

Hydraulic fracturing has become one jet of the most popular techniques for exploring sustainable energy sources.However, friction is associated with the entire fracturing process, presenting significant challenges for development.Facing the huge friction challenges, this review is elaborated in the following three aspects: (1) the fundamentals of h

Summary: As an essential step for brain morphogenesis, neurons migrate via mechanical interactions with components of their environment such as neighboring cells and the extracellular matrix.However, the molecular mechanism by which neurons exert forces on their environment during migration remains poorly understood.Here, we show that shootin1b is